Prime Minister Malcolm Turnbull and Foreign Minister Julie Bishop will spearhead Australia's presence at the Commonwealth Heads of Government Meeting in the UK this week.
They will join leaders and ministers from 53 member countries to address the need for trade, investment and good governance, as well as cybersecurity issues.
"Australia will be encouraging Commonwealth leaders to resist protectionism by making strong and practical statements in support of a free and open rules-based trading system," Ms Bishop said in a statement.
She will meet with numerous foreign ministers including British Foreign Secretary Boris Johnson to discuss a range of issues such as the recent use of a military grade nerve agent in an attempted assassination in Salisbury.
The minister will also address the Commonwealth Business Forum and participate in the Malaria Summit to discuss international efforts to combat malaria.
She will highlight Australia's work in the Indo-Pacific region and the important links between malaria elimination and the broader health security agenda.