Federal minister Christopher Pyne will learn on Friday whether his seat of Sturt will be recommended for abolition, sparking a battle with Liberal colleagues.
South Australia is due to lose one seat, going from 11 to 10, because its share of the national population is slowing.
The ACT and Victoria will each gain a seat, taking the total number of MPs in the House of Representatives to 151.
Labor has proposed to the Australian Electoral Commission - which will finalise the new boundaries in July - that there be three rural and seven metropolitan seats in SA.
The seat of Adelaide should be the "keystone" with boundary changes to its eastern and western edges, while Sturt would be absorbed into neighbouring seats to its north, west and south, the party argued.
However, the Liberal Party said Adelaide, which is held by the retiring Labor MP Kate Ellis, should be absorbed into its surrounding seats.
The Australian newspaper reported last year Mr Pyne had told SA party colleagues he would seek to stand in Boothby, held by first-term Liberal MP Nicolle Flint, if Sturt was abolished.
Mr Pyne, who is on his way to the United States for two days of defence talks, was first elected to parliament in 1993 and holds Sturt with a margin of just under six per cent.
The AEC needs to take into account not only the population of electorates but communities of interest, means of travel and physical features in redrawing boundaries.